 aidspml9a.jpg Axial PDW images show large confluent areas of hyperintensity of both centra semiovale, the posterior white matter, the left basal ganglia, and the splenium of the corpus collosum. There is relatively little mass effect for the size of these lesions. The cortex is predominantly spared. |
 aidspml9b.jpg Axial PDW images show large confluent areas of hyperintensity of both centra semiovale, the posterior white matter, the left basal ganglia, and the splenium of the corpus collosum. There is relatively little mass effect for the size of these lesions. The cortex is predominantly spared. |
 aidspml9c.jpg Axial autopsy specimen show extensive demyelination of the white matter bilaterally (arrowheads) |
 aidspml9d.jpg Axial autopsy specimen at different level than (C) shows demyelination of the splenium of the corpus collosum (arrowheads) and the posterior white matter (arrow). Microscopically, there was marked myelin loss and variable axonal loss of the white matter with numerous gemistocytic astrocytes, some of which had enlarged nuclei. In addition, foamy macrophages, multiple round oligodendrocytic type nuclei, and multinucleated cells were present. Chronic inflammatory reactions were infrequently noted. |