PML: Progressive Multifocal Leukoencephalopathy

WM Disease - JC Papova Virus

Ubiquitous Virus

• 70% of Adults have Ab to JC
• Almost 20% of HIV+ pts.have JC Ag

Causes 4% of AIDS Deaths

• PML => death in 4-6 months

Tx - AZT, and other anti-retroviral Rx