ANAPLASTIC ASTROCYTOMA

WHO Grade III

Cell of Origin: ASTROCYTE

Synonyms:

Common Locations: cerebral hemispheres, brainstem

Demographics:

Histology: astrocytes with anaplastic features: increased cellularity, pleomorphism, mitotic activity, and nuclear atypia

Special Stains: GFAP+

Progression : great probability of progression to glioblastoma

Radiology: Variable appearance for features of enhancement and surrounding edema. Necrosis (ring enhancement) does not occur, and cyst formation is extremely rare.

COMMENTS: This stage of astrocytoma is the least common, and may represent a short-term intermediate lesion during the transition from Grade II to Grade IV astrocytoma.