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CENTRAL NEUROCYTOMA
 

 
Sagittal T1W MR Axial T2W MR

 
 
 

WHO Grade I

Cell of Origin: Neurons

Common Locations: Intraventricular (Lat >> 3rd) (often attached to septum pellucidum)

Demographics: Young adults (mean age: 25-30)

Clinical Presentation: Nausea, vomiting, headache due to obstructive hydrocephalus.

Histology: Uniform appearance of small, round cells mimics oligodendroglioma. Electron microscopy may demonstrate neuronal features.

Special Stains: Purely neuronal origin demonstrated by neuronal markers (synaptophysin, neuronal specific enolase) and negativity to glial markers.

Progression: Slow-growing, benign tumor; no extraventricular extension. Resection usually curative.

Radiology: Well-circumscribed, lobulated intraventricular mass. Often (50%) with bulky calcifications, best demonstrated on CT. Isodense/slightly hyderdense on CT. May be isointense to gray matter on both T1 and T2-weighted MR images. MR often demonstrates small "cysts".

Comments: Previously misdiagnosed as intraventricular oligodendroglioma. Rare reports of extraventricular (parenchymal) location. Rarely, spontaneous intraventricular hemorrhage.