GLIOBLASTOMA MULTIFORME
 

Axial Gd Enhanced T1W MR	Axial T2W MR

WHO Grade IV

Cell of Origin: ASTROCYTE

Synonyms: GBM, glioblastoma multiforme, spongioblastoma multiforme

Common Locations: cerebral hemispheres, occasionally elsewhere (brainstem, cerebellum, cord)

Demographics: peak from 45-60 years

Histology: grossly heterogeneous, degeneration, necrosis and hemorrhage are common

Special Stains: GFAP varies, often present in areas of better differentiation

Progression : Can't get any worse.

Radiology: Glioblastoma is usually seen as a grossly heterogeneous mass. Ring enhancement surrounding a necrotic center is the most common presentation, but there may be multiple rings. Surrounding vasogenic edema can be impressive, and adds significantly to the mass effect. Signs of recent (methemoglobin) and remote (hemosiderin) hemorrhage are common. Despite it’s apparent demarcation on enhanced scans, the lesion may diffusely infiltrate into the brain, crossing the corpus callosum in 50-75% of cases.

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